The textbook is compiled in accordance with the requirements of the GEA HE in the specialty 31.05.01 "General Medicine", approved by the Ministry of Education and Science of the Russian Federation 12.08.2020,OrderNo. 988 and taking into account the professional standard "Doctor-physician (doctor - district therapist)", approved The Ministry of Labor and Social Protection of the Russian Federation of 21.03.2017 Order No. 293n. The textbook contains assignments that contribute to systematization, structuring and broadening of students' knowledge on the issues of therapeutic and surgical patient’s care. The working section contains questions of test control and self-control of knowledge, as well as questions for colloquiums. The textbook contains questions for test control and self-control, as well as the questions for colloquiums. The textbook is intended for students studying specialist degree programm 31.05.01 «General Medicine».